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Half of people suffering from depression feel more angry and irritable than anything else. In fact, those emotions are indicative of someone who’s severely depressed, according to psychiatrist Dr. Philip Muskin from Columbia University Medical Center. For example, they’ll start an argument at the drop of a hat, like when they walk in the door from work. Or they’ll get ultra-irritated at small things, like a stain on their shirt. If that sounds familiar, to you or a loved one, seek counseling. 80% of people with clinical depression respond to treatment.