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The answer is “NO.” According to neurobiologist Dr. Richard Wassersug, sneezing occurs when something irritates the nerve endings inside your nostrils. The nerves then send a message to your brain, which triggers a sneeze to eject the irritant. But if you’re asleep, your brain is relaxed…And the neurons that trigger a sneeze are turned off. However, Dr. Wassersug says if you happen to inhale something strong while you’re asleep – like a nose full of pepper, for example – your natural reaction will be to wake up firstand THEN sneeze.